iCOMOS Wednesday, May 2

Continental breakfast at 7:30 a.m. will be followed by an opening presentation, "Local to Global Prediction of Weather, Pestilence, Plagues and Famine." The remainder of the day will be devoted to these cutting-edge topics in concurrent interactive sessions:

  1. One Medicine One Science Approaches to Health at Two NIH Institutes
  2. Effective Policy when Consumer Preferences Do Not Match Actions
  3. Breaking Silos and Building Bridges Within and Across Geographies
  4. Precision Medicine and Genome Editing: Science and Ethics
  5. Science Communication and Strategic Engagement of Policy Makers

1: One Medicine One Science Approaches to Health at Two NIH Institutes

Coordinators: Hortencia Hornbeak, Peter Jackson, Kimberly Thigpen Tart, Heather Henry, National Institutes of Health (NIAID, and NIEHS – Joint)

This workshop will explore One Medicine One Science (OMOS) approaches applied at two NIH institutes to complex human health issues requiring coordinated, multi-disciplinary research programs and teams. Senior institute staff and funded investigators of the National Institute of Allergy and Infectious Disease (NIAID) and the National Institute of Environmental Health Sciences (NIEHS) will lead discussions of (a) Zika as a case study of an emerging disease and pandemic threat, and (b) studies of chronic disease resulting from the interactions of living systems with environmental threats such as chemicals and other contaminants that affect human health. Presentations will feature diverse NIH-supported OMOS-related research studies and will discuss methods and resources for integrating OMOS approaches into aspects of infectious disease and environmental research including surveillance, epidemiology, prevention and intervention, data collection and analysis, partnership building, and training and capacity building.

9:15-9:30 p.m.

Introduction: One Medicine, One Science at Two Institutes of the NIH

Hortencia Hornbeak, NIAID, NIH; Linda Birnbaum, Director, NIEHS, NIH


OMOS at NIAID: Zika Case Study

Moderator: Peter Jackson or Hortencia Hornbeak, NIAID

9:30-9:55 p.m.

Zika epi/control/pathology

Esper Kallas, U of Sao Paolo, Brazil

9:55–10:20 p.m.

Zika in infants and pregnancy study

José Cordero, University of Georgia, United States

10:20–10:35 p.m.

Refreshment Break

10:45−11:10 p.m.

Preclinical and clinical development of Zika virus vaccines

Dan Barouch, Harvard Medical School, United States                                                                                                                                    

11:10-11:35 p.m.

Vaccine preparedness for viral pandemics

Barney Graham, NIAID, NIH Vaccine Research Center, United States  

11:35-12:00 p.m.

Panel discussion and Q&A

12:00-1:00 p.m.

Networking Lunch


OMOS in Environmental Health Research 

Moderator: Heather Henry, NIEHS

1:00–1:25 p.m.

The use of sentinel species in health disparities research  

Frank Von Hippel, Northern Arizona University, United States.

1:25-1:50 p.m.

Chronic kidney disease, pollution and sentinel species in Sri Lanka

Nishad Jayasundara, University of Maine, United States.

1:50-2:15 p.m.

One Health approach to the impacts of the Deepwater Horizon oil spill

Maureen Lichtveld, Tulane University, United States.

2:15-2:35 p.m.

Q&A/Discussion

2:35-3:00 p.m.

Refreshment Break

3:00-5:10 p.m.

Programs, resources, and tools for integrating One Medicine, One Science approaches to health

Moderator: Kimberly Thigpen Tart, NIEHS

3:00-3:20 p.m.

Mechanisms and language that NIAID uses to support research in a OMOS framework

Peter Jackson, NIAID, NIH
and  

Programs and funding mechanisms used to support research in a OMOS framework: SRP (incl. SBIR/STTR, DR2)

Heather Henry, NIEHS, NIH

3:20-3:45 p.m.

Global training and capacity building

John Balbus, NIEHS, Global Environmental Health Program and WHO Collaborating Centre, United States

3:45-4:10 p.m. 

Building clinical research capacity

Gray Handley, NIAID, United States

4:10-4:35 p.m.

Global perspectives on access to bio-samples and data sharing

Yaffa Rubinstein, U.S. National Library of Medicine, United States

4:35–4:55 p.m.

Q&A/Discussion

4:55-5:10 p.m.

Wrap Up

Heather Henry, NIEHS, NIH; Peter Jackson, NIAID, NIH

5:10-6:00 p.m.

Small meetings with NIH administrators

2: Effective Policy when Consumer Preferences Do Not Match Actions

Coordinator: Shaun Kennedy, University of Minnesota

The public in general or a significant subset often drive specific food and health policies as governments and the private sector attempt to meet their expressed desires. The challenge for effective policy implementation, however, is that consumers do not always choose health behaviors or foods that are consistent with their priorities. This is especially challenging when consumers make choices based on one priority that appears to conflict with other expressed priorities. While not a new concept in philosophy or what is sometimes called moral mathematics, it is not generally applied when developing and implementing health and food policies. This is easy to understand when it is an economic priority, cost, overriding a personal priority, enhanced food safety, with simple choices such as not purchasing irradiated ground beef for food safety due to the cost of irradiation. It becomes far more complicated to implement effective policy when it is more nuanced such as consumers making health or food choices that are demonstrably less favorable to their own family’s health or the environment than alternatives. This workshop will look at how to consider health or food policies in the face of competitive, unexpressed or conflicting priorities and the extent to which the policies can achieve their objectives. It will draw beyond policy experts to include experts in consumer behavior, individual to group dynamics, game theory and economics from the academic, public and private sectors to consider policy differently.

Anticipated Outcomes from the Session and group discussion include at least two papers:  (1) On the similarities between outwardly very different policy areas (obesity, food safety, food security and autism; (2) Proposed new strategies to address these important policy areas.

Keynote

9:15-10:00 a.m.

Food and health policy in a time of unprecedented challenges Case Studies in Priorities and Choices Conflicts

10:00-10:30 a.m.

How consumers really make food purchasing decisions, not how they say they do

Darren Seifer, Industry Analyst - Food Consumption, The NPD Group

10:30-10:40 a.m.

Break

10:40-11:10 a.m.

Consumer behavior, policy and obesity (pending)

Sara Bleich, Radcliffe Institute for Advanced Study, Harvard University

11:10-11:40 a.m.

The politics surrounding autism

Dana Baker, California State University Channel Islands

11:40 a.m.-12:10 p.m.

Non-regulatory approaches to food security: Examples from Brazil

Cecilia Rocha, Ryerson University

12:10-1:30 p.m.

Networking Lunch

1:30-2:15 p.m.

Voting Procedures to Choose Leaders and Policies That Produce Consensus (Rather Than Division)

Steven Brams, New York University

2:15-3:15 p.m.

Exploring the gaps between policy and behavior

(Small Group Discussions)

3:15-3:35 p.m.

Reporting Back

3:35-4:30 p.m.

New strategies for regulatory and non-regulatory policy

(Small Group Discussions)

4:30-5:00 p.m.

Reporting Back and Conclusions

5:00 p.m.

Session ends

3: Breaking Silos and Building Bridges Within and Across Geographies for One Medicine, One Science: Workforce development needs and implementation programs

Coordinators: Andres Perez and Katey Pelican  University of Minnesota; Aziz Arda Sancak, Ankara University, Turkey

Despite an increasingly popular One Health rhetoric, authentic examples of multiple disciplinary efforts to transcend the traditional silos of public, animal, and environmental health are still rare. The ultimate goal of COMOS is to contribute to securing food and protecting health of human, animals, and the environment through a network of equal partners. Prerequisite for accomplishing that goal is the development of the required workforce to identify problems and provide solutions to recurrent and emerging grand challenges regionally and globally. In this workshop, we will provide an overview of needs assessment and implementation programs in the areas of food animal trade and one health. Capacity building programs, including issues related with needs assessment, implementation, and evaluation, for veterinary and public health will be presented. Multisectoral approaches to identify and address emerging needs and issues will be introduced. Regional perspectives on gaps and challenges will be discussed. Finally, a debate focused on particular opportunities identified during the session for workforce development at regional and global scales will be promoted.  

Audience Scientists, intergovernmental organizations, students, industry partners, and stakeholders engaged or interested in workforce development and education on ecosystems health, agribusiness, food production, economics and policy regionally and globally.

Outcome

1. A “perspective” paper outlining the vision for workforce development in the context of COMOS

2. Proposals for workforce development and capacity building of veterinary services and One Health, promoting regional and global alliances

3. Outline plans for the organization of iCOMOS in the Ibero-American region in 2020

Timeline

Completion of paper within 3 months of the workshop to be shared with funding agencies and sponsors. Continue to support regional activities for COMOS.

Scientific value

Outline of a plan for development of educational and outreach programs in the context of COMOS

Session 1 

Unfolding the OMOS paradigm shift through capacity building programs

Moderator: Andres Perez, University of Minnesota

9.15-9.30 a.m.

Presentation, introduction, and expectations

Andres Perez

9.30-10.05 a.m.

Implementing programs for capacity building at a global scale – Joint presentation

Speakers from the OIE collaborating centers on capacity building:

Agnes LeBlond, ENSV, Lyon, France
Emilio León, CEBASEV, Buenos Aires,  Argentina

10.05-10.20 a.m.

Break

10.20-10.50 a.m.

Field Epidemiology Training Program (FETP) and Field Epidemiology Training Program for Veterinarians (FETPV): expanding the global public health workforce across human and animal health

Stephanie Salyer, CDC, United States

10.50-11.20 a.m.

Building global and national capacity to meet international public health standards

Stephane De La Rocque, WHO, France

11.20-11.50 a.m.

Challenges and opportunities on building a global One Health Workforce

Katey Pelican, University of Minnesota, United States

11.50 a.m.-12.00 p.m.

Conclusions and introduction to Session 2

Andres Perez, University of Minnesota, United States

12.00-1.30 p.m.

Lunch Break

Session 2

Diagnosing regional gaps and emerging challenges to prioritize multisectoral opportunities

Moderators: Aziz Arda Sancak, Ankara University, Turkey and Katey Pelican University of Minnesota, United States

1.30-1.40 p.m.

Emerging issues in Latin America and emerging needs for workforce development

Enrique Perez, PAHO, United States

1.40-1.50 p.m.

Improving multisectoral health responsibility in Turkey: opportunities and challenges for health

Irfan Sencan, Turkish Public Health Institute, Ministry of Health, Turkey

1.50-2.00 p.m.

Emerging needs and opportunities for capacity building in aquaculture

Fernando Mardones, Universidad Andres Bello, Chile

2.00-2.10 p.m.

Emerging needs and opportunities for capacity building in Western Africa

Ouri Bassa Gbati, Ecole Inter Etats des Sciences et Medecine Veterinaires, Dakar, Senegal

2.10-2.20 p.m.

Emerging needs and opportunities for capacity building in Southern Asia

Tongkorn Meeyam, Chiang Mai University, Thailand

2.20-3.00 p.m.

Interactive discussion - Table topics

3.45-4.15 p.m.

Roundtable synthesis & reflections / Final remarks 

4: Precision Medicine and Genome Editing: Science and Ethics

Coordinators: Cliff Steer and Pamala Jacobson, University of Minnesota; Kavita Berger, Gryphon Scientific

According to the NIH, precision medicine is "an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each person." It refers to the tailoring of medical treatment to the individual characteristics of each patient and the ability to classify individuals into subpopulations that differ in the biology, susceptibility and response to treatment for a particular disease. In January 2015, the US President launched the Precision Medicine Initiative (PMI), a bold new research effort to revolutionize how we improve health and treat disease, empowering health care providers to tailor treatment and prevention strategies to individuals’ unique characteristics.  Gene editing uses engineered nucleases or so-called “molecular scissors” to make changes to specific DNA sequences in the genome of a living organism. They include meganucleases, zinc finger nucleases (ZFNs), transcription activator-like effector-based nucleases (TALENs), and the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas system. Genome editing is being developed to treat not only genetic diseases but also infectious diseases and those that have both a genetic and an environmental component.  It is now widely used in biomedical research, including creation of disease models with desired genetic mutations, screening in a high-throughput manner for drug resistance genes, and making appropriate editions to genes in vivo for disease treatment.  All of these applications have been facilitating the development of precision medicine research. 

9:15 a.m.

Welcome Clifford Steer, University of Minnesota

9:30 a.m.

Rewriting the Genome

Speakers will discuss the state-of-the-science for precision medicine and genome editing, highlighting the key advances and limitations of each. Speakers will discuss new applications enabled by precision medicine and/or genome editing. Moderator: Clifford Steer, University of Minnesota

9:35 a.m. 

Gene editing enters the food supply

Dan Voytas, University of Minnesota, United States

10:00 a.m.

Precision swine models of human disease by gene editing

Dan Carlson, Recombinetics, Inc,, United States

10:25 a.m.

Targeted nucleases for finding cancer drivers and vulnerabilities

David Largaespada, University of Minnesota, United States

10:45 a.m. 

Coffee Break

11:00 a.m.

Precision public health? The evolving paradigm in health and medicine

Speakers will discuss the implications of precision medicine on public health, describing specific examples where precision medicine limit or enhance public health. Speakers will highlight specific challenges and describe approaches for addressing those challenges.  

Moderator: Pamala Jacobson, University of Minnesota

11:10 a.m.

Personalized medicine vs. public health: contradictory or complementary?

Nancy Cox, Vanderbilt University, United States

11:35 a.m.

Integrating pharmacogenomic information into practice                                           

Richard Weinshilboum, Mayo Clinic, United States

12:00 p.m. 

To be determined

12:30 p.m. 

Lunch

1:30 p.m. 

Societal Considerations of Ethics, Safety, and Security Speakers will discuss the ethical, safety, and security concerns associated with precision medicine and/or genome editing.

Moderator: Kavita Berger, Gryphon Scientific

1:40 p.m. 

Can we ethically modify our genomes?  

Debra Mathews, Johns Hopkins University, United States

2:05 p.m.

Safeguarding the Bioeconomy

Edward You, U.S. Federal Bureau of Investigation, United States

2:30 p.m. 

Ensuring the safety of human genome editing at home and abroad

Gary Marchant, Arizona State University, United States

3:00 p.m.

Coffee Break

3:20 p.m.

Pros and cons: applications of Precision Medicine and Genome Editing

The moderator will prompt discussants to consider and describe the pros and cons of precision medicine, genome editing, and the integration of both fields towards human health.

Moderator: To be determined

Panelists will be selected from speaker pool

4:30 p.m.

Adjourn

5: Science Communication and Strategic Engagement of Policy Makers

Coordinators: Dominic Travis, University of Minnesota; Emily Cloyd, American Association of Advancement of Science (AAAS)

Join your colleagues for an American Association for the Advancement of Science Communicating Science workshop specifically designed to help you plan and participate in a wide variety of public engagement activities. During this workshop, you will develop your public engagement and science communication skills through discussion, self-reflection, small-group work and practice sessions. The workshop focuses on the importance of effective, two-way communication and is designed to enable you to engage in meaningful, reciprocal dialogue with diverse audiences. When the session is complete, you will be able to clearly identify a public engagement goal, define a relevant audience, and craft and rehearse messages tailored to that audience.

9:15 a.m.-12:15 p.m.  

Science Communication and Public Engagement Fundamentals

Emily Cloyd, American Association for the Advancement of Science, United States

The flagship Science Communication and Public Engagement Fundamentals module focuses on the core components of successful public engagement. Participants are introduced to the AAAS public engagement framework, a guide they can apply to all kinds of interactions. Participants learn how to identify a public engagement goal, determine the relevant audience, craft tailored messages to achieve their goal and rehearse their engagement scenario.

1:15-4:15 p.m. 

Engaging Policymakers

Emily Cloyd, American Association for the Advancement of Science, United States

The Engaging Policymakers module provides an overview of the science policy landscape and the role of science and scientists in the policy process. This workshop introduces basic best practices for engaging in dialogue with this target audience at a local, state or national level. Participants identify individual communication goals and develop short messages that will resonate with policy audiences.